Transfusion-Related Acute Lung Injury (TRALI) and Strategies for Prevention
نویسنده
چکیده
Background: Transfusion-Related Acute Lung Injury (TRALI) is a serious complication of blood transfusion. In recent years, TRALI has been reliably shown to be the most common cause of transfusion-related fatalities in the United States and in the United Kingdom. Its prevalence is about 1 in 1323 transfused components; however, it is often under diagnosed. Classically, TRALI present as noncardiogenic pulmonary oedema. Management is mainly supportive with 72% of cases requiring ventilatory support.
منابع مشابه
Transfusion-related acute lung injury in multiple traumatized patients
Background: Many of the multiple traumatized patients who refer to the hospital need transfusion. Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. In the article, we present a case of TRALI following transfusion of packed red blood cells Case Presentation: A 24 year old male referred to Shahid Beh...
متن کاملTransfusion-related acute lung injury; clinical perspectives
Transfusion-related acute lung injury (TRALI) was introduced in 1983 to describe a clinical syndrome seen within 6 h of a plasma-containing blood products transfusion. TRALI is a rare transfusion complication; however, the FDA has suggested that TRALI is the leading cause of transfusion-related mortality. Understanding the pathogenesis of TRALI will facilitate adopting preventive strategies, su...
متن کاملTransfusion-related acute lung injury: a literature review.
Transfusion-related acute lung injury (TRALI) is a serious and potentially fatal complication of transfusion of blood and blood components. TRALI is under-diagnosed and under-reported because of a lack of awareness. A number of models have been proposed to explain the pathogenesis of TRALI: an antibody mediated model; a two-event biologically active mediator model; and a combined model. TRALI c...
متن کاملRole of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury.
INTRODUCTION Risk reduction strategies for transfusion-related acute lung injury (TRALI) include the preferential use of male donors to provide fresh frozen plasma (FFP). Implementing this measure based on FFP quarantine program is a very complex process. To improve FFP inventory management and the availability of FFP from male donors, the Mirasol Pathogen Reduction Technology(®) (PRT) system f...
متن کاملTesting only donors with a prior history of pregnancy or transfusion is a logical and cost-effective transfusion-related acute lung injury prevention strategy.
BACKGROUND Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatality reported to the Food and Drug Administration. Donor screening may reduce TRALI risk. This study sought to compare the efficacy and safety of different TRALI risk-reduction strategies at a hospital-based donor center. STUDY DESIGN AND METHODS Samples from 1053 donors who answered quest...
متن کامل